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Irbesartan and Hydrochlorothiazide tablets are contraindicated in patients who will be hypersensitive to any element of the item. Because of the hydrochlorothiazide ingredient, this products is contraindicated in people with anuria or hypersensitivity to other sulfonamide-derived medicine.
Irbesartan: Angiotensin II is often a powerful vasoconstrictor formed from angiotensin I in a very reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is definitely the principal pressor agent from the RAS and in addition stimulates aldosterone synthesis and secretion by adrenal cortex, cardiac contraction, renal resorption of sodium, activity of the sympathetic nervous procedure, and clean muscle cell progress.
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Irbesartan's avoidance of angiotensin II binding brings about vascular smooth muscle mass peace and stops the secretion of aldosterone, decreasing blood pressure.
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